Howard Jacob, PhD

Howard Jacob High Res photoHoward Jacob, PhD, is a Faculty Investigator and Executive Vice President for Genomic Medicine at the HudsonAlpha Institute for Biotechnology. Dr. Jacob uses molecular genetics to understand complex, multifactorial disease. His passion for improving the lives of critically ill patients has been the catalyst for his determination to bring whole genome sequencing into a clinical setting. Dr. Jacob received his PhD in pharmacology from the University of Iowa in 1989. He completed two parallel postdoctoral fellowships in functional genomics and molecular genetics and genomics at Harvard, Stanford and MIT. He was on the faculty at Massachusetts General Hospital and Harvard Medical School before moving to the Medical College of Wisconsin in Milwaukee. Dr. Jacob was the founding director of the Human and Molecular Genetics Center as well as the Warren P. Knowles Chair of Genetics and a professor in the departments of physiology and pediatrics at MCW, positions he held for nearly 20 years. He joined the HudsonAlpha Institute for Biotechnology in 2015.

In his role as Executive Vice President for Genomic Medicine, Jacob leads the clinical genomics team at HudsonAlpha and is heavily involved in its two clinical enterprises– the Smith Family Clinic for Genomic Medicine and the Clinical Services Lab. The Smith Family Clinic is believed to be the world’s first stand-alone genomic medicine clinic devoted exclusively to the use of whole genome sequencing for the diagnosis of rare undiagnosed and misdiagnosed disease. The Clinical Services Lab offers CAP/CLIA whole genome sequencing and interpretation. Jacob also runs a research lab at HudsonAlpha. His research focus is verification of specific changes to DNA that are disease causing, and pinpointing those genetic changes quickly enough to benefit patients.

Dr. Howard Jacob has published more than 250 peer-reviewed papers, abstracts and book chapters. He has served on the editorial boards for multiple peer-reviewed journals, NIH study sections, and is currently a member of the National Advisory Board for the National Human Genome Research Institute.

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